Frequently Asked Questions

An Informed Consent document will be given to you before you join the study. This document outlines the key facts about the Vibrato research study, including the risks and benefits of taking part, so you can consider what is involved, ask any questions and decide if you want to go ahead and sign the document. No study-related procedures will take place without a signed Informed Consent document.

A study investigator is a medical researcher in charge of conducting a clinical research study and ensuring the wellbeing of study volunteers. The investigators involved with the Vibrato research study are all qualified licensed physicians and medical specialists.

An investigational medicine is a research study drug that has not yet been approved by the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA), or similar agencies in other countries, for prescription by doctors.

You will be provided with packs or bottles of tablets for you to take at home, once a day, except on the days when you have a study center visit. On those days, you should take the pack/bottle with you and take your medication during your scheduled appointment.

Yes, you could be given a placebo. The study doctor will be able to help you understand your chances of getting a placebo in the induction phase of the study. Neither you nor your study doctor will know if you are given a placebo or active drug in the induction phase of the study. In the chronic therapy phase of the study there is no placebo. All subjects will be given investigational medicine.

PF-06651600 is an investigational drug. It is an oral medication.

PF-06700841 is an investigational drug. It is an oral medication.

At this stage, it will not be possible to continue with the investigational medicine.

There are risks associated with taking an investigational medication. You may experience side effects or find that your symptoms are not improved or even increase in severity. It is important that you mention any concerns to your study doctor.

Our clinical research study has been set up to investigate the effects of the study drugs PF-06651600 and PF-06700841 on ulcerative colitis and, whilst there is no known direct benefit to taking part, the results of this research could potentially improve the quality of life for millions of people living with UC worldwide. You will receive study-related care at no cost and you will be closely monitored by a dedicated medical team for study-related purposes, during this study.

You are completely free to leave the study at any time without giving a reason. The decision to leave the study will not affect your future medical care by your physician in any way.

Information about your personal health will be kept private and confidential. With your permission, the information you provide via the pre-screening form on this website about your medical history and health condition will be transferred to the Vibrato study team. A representative from the study team will contact you to further determine your interest and eligibility. Your personal information will not be disclosed to anyone outside of this clinical research study group without your consent unless disclosure is required by law or regulations of the FDA, EMA, or similar agencies in other countries.